Tuesday, November 21, 2017
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CONTACTS 

Phone: (706) 721-7149
Email:holiu@augusta.edu
Room: CA 4096
Address:
Medical College of Georgia,
CBGM, 1120 15th Street,
CA 4094,
Augusta, GA 30912
MCG Faculty Page


EDUCATION 


Ph.D.,Immunology
Jilin University  China
MS, Biochemistry
Jilin University  China
BS, Biochemisty
Jilin University  China

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HONGYAN LIU: 
       ASSISTANT PROFESSOR
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General Information
The advances of nanotechnology provide paradigm-changing opportunities for disease diagnostic and therapy. The research in my lab will focus on developing new nanomaterials and methodologies for probing disease markers at single-cell and single-molecule level, and delivery siRNA and chemical drugs for targeting therapy.

Quantum dots (QDs), light-emitting nanocrystals, possess unique properties such as size-tunable emission, super brightness,outstanding photostable, abroad absorption spectra that enable the simultaneous excitation of multiple fluorescence colors. We will use new bioconjugation techniques for QD functionalization.The methodologies on QD-based IHC and in vivo imaging will be developed and translated into real-world application.

SiRNA –based gene therapy has broad potential to silence any disease genes. To achieve the clinical application of siRNA,we will build a variety of delivery carriers including proteins, nanoparticles and nucleic acids. Targeting delivery of chemical drugs will be performed to provide new distribution profile on conventional chemotherapy drugs.

Bispecific antibodies are promising to treat malignant cancers and infectious diseases. We will use gene engineering and bioconjugation strategies to develop bifunctional molecules for large-scale bispecific antibody screening, which will lay out foundation for discovery of new therapeutic targets.

Grant(s)

  Department of Defense:  W81XWH-15-1-0333  8/15/2015-8/14/2018

 



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RESEARCH PROJECTS
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PUBLICATIONS
  • Liu, HY*. et al. Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer. Sci. Rep. 6, 30346; doi: 10.1038/srep30346 (2016).  * First and corresponding author.  
  • Liu HY, Zrazhevskiy P, Gao X. Solid-Phase Bioconjugation of Heterobifunctional Adaptors for Versatile Assembly of Bispecific Targeting Ligands. Bioconjug Chem.25(8),1511-6 (2014)
  • Liu,HY. & Gao, X. A Universal Protein Tag for  SiRNA-Aptamer Chimeras. Sci. Rep.3,3129; DOI:10.1038/srep03129 (2013).
  • Liu, HY. and  X. Gao "Engineering monovalent quantumdot-antibody bioconjugates with a hybrid gel system." Bioconjug Chem.22(3): 510-7 (2011) 
  • Vu TQ, Liu HY. Quantum dot hybrid gel blotting: a technique for identifying quantumdot-protein/protein-protein interactions. Methods Mol Biol.  544:381-91 (2009)
  • Scholl B, Liu HY, Long BR, McCarty OJ, O'Hare T,Druker BJ, Vu TQ. Single particle quantum dot imaging achieves ultrasensitivedetection capabilities for Western immunoblot analysis. ACS Nano.  23; 3(6): 1318-28 (2009)
  • Rajan SS, Liu HY, and Vu TQ Ligand-Bound Quantum Dot Probes for Studying theMolecular Scale Dynamics of Receptor Endocytic Trafficking in Live Cells. ACS Nano.2(6), 1153–1166 (2008)
  • Liu HY and Vu TQ. Identification of QuantumDot Bioconjugates and Cellular Protein Co-localization by Hybrid Gel Blotting. Nano Letters. 7(4): 1044-9 (2007)
  • Vu TQ, RajanSS, Liu HY. Ligand Bound Quantum Dots for Intracellular Imaging ofNeural Receptors. Proc.of SPIE.Vol.6448, 644813 (2007)
  • Liu HY, Zheng G, Zhu H, Woldegiorgis G. Hormonal andnutritional regulation of musclecarnitine palmitoyltransferase I geneexpression in vivo. Arch Biochem Biophys. 465(2):437-42 (2007)
  • Pejovic T, Yates JE, Liu HY, Hays LE, Akkari Y, Torimaru Y,Keeble W, Rathbun RK, Rodgers WH, Bale AE, Ameziane N, Zwaan CM, Errami A,Thullier P, Cappuccini F, Olson SB, Cain JM, Bagby GC Jr. Cytogeneticinstability in ovarian epithelial cells from women at risk of ovarian cancer. Cancer Res. 66 (18):9017-25 (2006)
  • Liu HY., Zheng G, Dai J, Woldegiorgis G.Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. J Biol Chem.280(6):4524-4531 (2005)
  • Liu HY, Buenafe AC, Matejuk A, Ito A, Zamora A, Dwyer J,Vandebark AA, offner H. Estrogen inhibition of EAE involves effects ondendritic cell function. J Neuroscience Res. 70(2):238-48 (2002)
  • Liu HY, Yang G.  The expression of VCAM-1 and MHC class II molecules on the EAE brain vascular endothelial cells. Acta Anatomica Sinica.2002, 33(2):215-218 
  • Liu HY, Yang G.  The purification of myelin basic protein and the effect of it on PBMC producingTNFα and IFNγ. Chinese Journal of Neuroimmunology and Neurology. 2001, 8(3):148-150 
  • Liu HY, Yang G. Using the phage small peptides containingVCAM-1 core epitope to experimentally treat EAE. Chinese Journal of Neuroimmunology and Neurology.2001,8(3):145-147 
  • Liu HY, Yang G. The expression of VCAM-1 on experimental autoimmune encephalomyelitis brain vascular endothelium and the effect of VCAM-1 on the Lymphocyte—endothelium adhesion. Journal of Norman Bethune University of Medical Siences.2001, 27(4):350-352   
  • Liu HY, Yang G.The endothelial cells incubating with the supernatant of MBPstimulated PBMC can promote T lymphocytes proliferation .Chinese Journal of Cellular and MolecularImmunology. 2001,17(2), 112-114  
  • Liu HY, Yang G.The myelin basic protein promote the adhesion effect of monocytes to endothelial cells. Chinese Journal of Immunology. 2000, 8(16):29-32 
  • Liu HY, Yang G.The advance on the signal transduction pathwayof FAK stimulated by integrin. Foreign Medical Sciences Section on immunology. 2000, 23(1)1-5
  • Liu HY, Yang G. The distribution and function of integrin onadult central nervous system. Foreign Medical Sciences Section on Immunology.1999, 22(5):245-248   
  • Liu HY, Yang SJ. et al. The chemical modification of the Trpresidues and sulfhydryl group of Bacillus Licheniformis A.4041 thermostablea-amylase. Acta Scientiarum Naturalium Universitatis Jilinensis.1997,(1):99-101

 PATENTS

  1.  Liu HY  and  Vu TQ. “A Method forSeparation and Identification of Proteins Using

    Unconventional Gel Electrophoresis and Detection of Single NanoparticleProbes” WO/2008/051985

      2. Gao X & Liu HY.  Protein tag for delivery ofsiRNA-aptamer chimeras.  PCT/US14/61714. 2014





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