Saturday, January 20, 2018



Phone: (706) 721-6335

Fax:     (706) 721-3688


Room: CA-4094


Georgia Regents University,
CBGM, 1120 15th Street,
Augusta, GA 30912

GRU Faculty Page


Ph.D.  Genomic Medicine / Bioinformatics

Georgia Regents University, Augusta, GA

General Information
My research focus is development of biologically meaningful algorithms for comprehensive analysis and visualization of high throughput data by incorporating biological knowledge and rigorous computational/statistical methods. I work with an interdisciplinary team to carry out bioinformatics analysis and pursue research projects in collaboration with other biologists. In our center we use high-throughput experimental methodologies such as gene expression microarrays, physical and genetic interaction mapping, genomic sequencing, and tandem mass spectrometry.  Both computational and biological aspects are required for analysis of these data for greater understanding of molecular processes. 

My research interests are:
• To develop algorithms and analytic approaches for genomic and proteomic data analysis and integration. 
• Solve the challenges in genomic data analysis, and implement these solutions in usable software tools.
• Working with an interdisciplinary team, carry out bioinformatics analyses, and pursue research projects in collaboration with other biologists.
• To integrate microRNA expression and mRNA expression data. 
• Independently utilize web resources (such as Entrez, RefSeq, GEO, BLAST), visualization tools, genome assemblies, and available analysis software to analyze genomic data.
• Establish procedures and work-flow for routine data analysis.

Course Director: GNMD 8050: Computatinoal Methods in Genomics and Genetics

Zhi W, Ferris D, Sharma A,Purohit S, Santos C, He M, Ghamande S, She JX.
Twelveserum proteins progressively increase with disease stage in squamous cellcervical cancer patients. Int J Gynecol Cancer.2014 Jul;24(6):1085-92. doi: 10.1097/IGC.0000000000000153.

Jin Y, Sharma A,Bai S, Davis C, Liu H, Hopkins D, Barriga K, Rewers M, She JX.
Riskof type 1 diabetes progression in islet autoantibody-positive children can befurther stratified using expression patterns of multiple genes implicated inperipheral blood lymphocyte activation and function. Diabetes. 2014Jul;63(7):2506-15. doi: 10.2337/db13-1716. Epub 2014 Mar 4.

Dun B, Sharma A,Xu H, Liu H, Bai S, Zeng L, She JX.
Transcriptomicchanges induced by mycophenolic acid in gastric cancer cells. Am J Transl Res. 2013Dec 1;6(1):28-42. eCollection 2013.

Dun B, Sharma A,Teng Y, Liu H, Purohit S, Xu H, Zeng L, She JX.
Mycophenolicacid inhibits migration and invasion of gastric cancer cells via multiplemolecular pathways. PLoS One. 2013 Nov15;8(11):e81702. doi: 10.1371/journal.pone.0081702

Wang J, Sharma A,Ghamande SA, Bush S, Ferris D, Zhi W, He M, Wang M, Wang X, Miller E, HopkinsD, Macfee M, Guan R, Tang J, SheJX.
Serumprotein profile at remission can accurately assess therapeutic outcomes andsurvival for serous ovarian cancer. PLoS One. 2013 Nov11;8(11):e78393. doi: 10.1371/journal.pone.0078393

Dun B, Xu H, Sharma A,Liu H, Yu H, Yi B, Liu X, He M, Zeng L, She JX.
Delineationof biological and molecular mechanisms underlying the diverse anticanceractivities of mycophenolic acid. Int J Clin Exp Pathol.2013 Nov 15;6(12):2880-6

Jin Y*,  Sharma A*, Carey C*, Hopkins D, Wang X, Robertson DG, Bode B, Anderson SW, Reed JC, Steed RD, Steed L, She JX.  
The expression of inflammatory genes is upregulated in peripheral blood of patients with type 1 Diabetes. Diabetes Care, 36:1–9, 2013.

Chen B, Yi B, Mao R, Liu H, Wang J, Sharma A, Peiper S, Leonard WJ, She JX. 
Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes. PLoS One. 2013;8(2):e56600, 2013; PMID: 23457589.

Lu S*, Purohit S*, Sharma A*, Zhi W*, He M, Wang Y, Li CJ, She JX. 
Serum Insulin-like growth factor binding protein 6 (IGFBP6) is increased in patients with type 1 diabetes and its complications. Int J Clin Exp Med. 2012; 5(3): 229–237; PMID: 22837797.

Zhi W*, Sharma A*, Purohit S, Miller E, Bode B, Anderson SW, Reed JC, Steed RD, Steed L, Hopkins D, She JX. 
Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays. Molecular & Cellular Proteomics, 2011: 10: M111.012203. (Impact Factor 9.876); PMID: 21900154.

Sharma A, Zhao J, Podolsky R, McIndoe RA. 
ParaSAM: a parallelized version of the significance analysis of microarrays algorithm. Bioinformatics 2010: 26: 1465-7; PMID: 20400455.

Sharma A*, Bartell SM*, Baile CA, Chen B, Podolsky RH, McIndoe RA, She JX. 
Hepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice. PLoS.One. 2010: 5(8): e12147; PMID: 20808936.

Sharma A, Podolsky R, Zhao J, McIndoe RA. 
A modified hyperplane clustering algorithm allows for efficient and accurate clustering of extremely large datasets. Bioinformatics 2009: 25: 1152-7; PMID: 19261720.

Kraj P*, Sharma A*, Garge N, Podolsky R, McIndoe RA. 
ParaKMeans: Implementation of a parallelized K-means algorithm suitable for general laboratory use. BMC Bioinformatics 2008: 9: 200; PMID:18416829

Zhou L, Wang H, Zhong X, Jin Y, Mi QS, Sharma A, McIndoe RA, Garge N, Podolsky R, She JX. 
The IL-10 and IFN-gamma pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells. Genome Biology. 2008: 9: R119; PMID:18664279.

Nguyen CQ, Sharma A, She JX, McIndoe RA, Peck AB. 
Differential gene expressions in the lacrimal gland during development and onset of keratoconjunctivitis sicca in Sjogren's syndrome (SJS)-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Exp.Eye Res. 2009: 88: 398-409; PMID: 19103199.

Nguyen CQ, Sharma A, Lee BH, She JX, McIndoe RA, Peck AB. 
Differential gene expression in the salivary gland during development and onset of xerostomia in Sjogren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse. Arthritis Res.Ther. 2009: 11: R56; PMID:19379516.

Peck AB, Saylor BT, Nguyen L, Sharma A, She JX, Nguyen CQ, McIndoe RA. 
Gene expression profiling of early phase Sjögren’s syndrome in C57BL/6.NOD-Aec1Aec2 mice identifies focal adhesion (FA) maturation associated with infiltrating leukocytes. (Invest Ophthalmol. Vis. Sci. 2011: 52(8): 5647-55; PMID: 21666236.

Peck AB, Nguyen CQ, Sharma A, McIndoe RA, She JX.
The interferon-signature of Sjögren’s Syndrome: What is it and what does it mean? (J Clin Rheumatol & Musculoskeleton Med. 09-May-2011).
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