Tuesday, November 21, 2017
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CONTACTS

Phone: (706) 721-3507

Email: shsharma@augusta.edu  

Room: CA-4139 

Address:
Augusta University
CBGM, 1120 15th Street,
CA-4139,
Augusta, GA 30912
GRU Faculty Page


EDUCATION


Ph.D.
University of Lucknow, India
 
MS
University of Lucknow, India
 
BS
University of Lucknow, India
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SHRUTI SHARMA, Ph.D 
 Assistant Professor
CENTER FOR BIOTECHNOLOGY AND GENOMIC MEDICINE
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GENERAL INFORMATION

My lab conducts research on vascular dysfunction, inflammation, oxidative and nitrosative stress in cardiovascular diseases and microvascular complications associated with diabetes. My current research focus is on endothelial dysfunction and vasculopathy associated with diabetic retinopathy. My research interests are as below:

  • Role of IL-6 trans-signaling in diabetic retinopathy
  • Carnitine homeostasis and their role in maintaining normal mitochondrial function.
  • Arginine recycling and nitric oxide signaling

EDITORIAL BOARD

Specialty Chief-Editor; Frontiers in Oxidant Physiology (impact factor 4.031)
http://journal.frontiersin.org/journal/physiology/section/oxidant-physiology

TEACHING

Course Director,Genomic Medicine seminar (GNMD8060)

Course Director, Translational Genomics and Proteomics (GNMD8051)

ONGOING RESEARCH FUNDING

NIH/NEIR01 Grant: 1R01EY026936-01: Sharma (PI)         09/01/2016– 08/31/2020       

Targeting Interleukin-6 Trans-signaling in Diabetic Retinopathy

The goal of this project is to test a novel therapeutic approach by targeting the IL-6 trans-signaling pathway using a pharmacological compound sgp130Fc, for the treatment of retinal vascular pathology and inflammation associated with diabetes.

COMPLETED RESEARCH PROJECTS

11SDG7460024: Sharma (PI); 07/01/2011- 06/30/2016

Scientist Development Grant from American Heart Association

Arginine recycling in Pulmonary Hypertension

09BGIA2310050: Sharma (PI); 07/01/2009 - 06/30/2011                 

Beginning Grant-in-Aid from American Heart Association                                                   

Disruption of Glutathione Homeostasis and Endothelial Apoptosis in Acute Lung Injury

Seed Grant: Sharma (PI); 07/01/2012 - 06/30/2013             

Seed Grant: Sharma (PI); 07/01/2009 - 06/30/2010             

Cardiovascular Discovery Institute, MCG, Augusta, GA

 

PUBLICATIONS

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/44452746/?sort=date&direction=descending

1.   Sharma A, Purohit S, Shruti Sharma, Bai S, Zhi W, Ponny SR, Hopkins D, Steed L,Bode B, Anderson SW, She JX. IGF-Binding Proteins in Type-1 Diabetes Are More Severely Altered in the Presence of Complications. Front Endocrinol. 2016 Jan29;7:2.PMID: 26858687

2.   Rafikova O, Rafikov R, Kangath A, Qu N, Aggarwal S, Shruti Sharma, Desai J,Fields T, Ludewig B, Yuan JX, Jonigk D, Black SM. Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension. Free RadicBiol Med. (2016)    Feb 27;95:96-111. PMID: 26928584

3.   Shruti Sharma, Sharad Purohit, A Sharma, Diane Hopkins, Leigh Steed, BruceBode, Stephen W. Anderson, Ruth Caldwell, JX She. Elevated Serum Levels ofSoluble TNF Receptors and Adhesion Molecules Are Associated with DiabeticRetinopathy in Patients with Type-1 Diabetes. Med. of Inflammation (2015).

4.   Xutong Sun, Sanjiv Kumar, Shruti Sharma,S Aggarwal, Qing Lu, C Gross, Olga Rafikova, SG Lee, S Dasarathy, Yali Hou, ML Meadows,W Han, Y Su, JR Fineman, SM Black. Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase. Am J Respir Cell Mol Biol. (2014)

5. Saurabh Aggarwal, C Gross, S Kumar, C Dimitropoulou, Shruti Sharma, BA Gorshkov, S Sridhar, QingLu, NV Bogatcheva, AJ Jezierska-Drutel, R Lucas, AD Verin, JD Catravas, SMBlack.  Dimethylargininedimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury. Am J RespirCell Mol Biol. (2014)

6.   Saurabh Aggarwal, CM Gross, Shruti Sharma, JR Fineman, SM Black. Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol. (2013)

7.   Ruslan Rafikov, Christiana Dimitropoulou, SaurabhAggarwal, A Kangath, Christine Gross, Daniel Pardo, Shruti Sharma, A Jezierska-Drutel, V Patel, C Snead, RLucas, A Verin, D Fulton, JD Catravas, SM Black. Lipopolysaccharide inducedlung injury involves the nitration-mediated activation of RhoA. J Biol Chem.(2014)

8.   *Shruti Sharma,*Angela Aramburo,Xutong Sun, Ruslan Rafikov, Sanjiv Kumar, Peter Oishi, Sanjeev Datar, GaryRaff, Sohrab Fratz, Jeffrey Fineman, Stephen Black ‘L-Carnitine PreservesEndothelial Function in a Lamb Model of Increased Pulmonary Blood Flow’ Pediatric Research(2013).

9.  Shruti Sharma, Jubilee Barton, RuslanRafikov, Saurabh Aggarwal, Hsuan-Chang Kuo, Peter Oishi, Sanjeev Datar, JeffreyFineman, Stephen Black. ‘Chronic Inhibition of PPAR-g Signaling InducesEndothelial Dysfunction In The Juvenile Lamb.’ Pulmonary Pharmacology and Therapeutics (2012).

10. Shruti Sharma, Xutong Sun, Saurabh Aggarwal, Ruslan Rafikov, Sanjiv Kumar,Stephen Black. ‘Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells’. Int Jour Molecular Science (2012).

11. Shruti Sharma,* Xutong Sun,*Sanjiv Kumar, Ruslan Rafikov, Angela Aramburo, Gokhan Kalkan, Jing Tian, ImranRehmani, Suphin Kallarackal, JR Fineman, SM Black.    Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Free Radic Biol Med., 53:216-29. Epub 2012.

12. SaurabhAggarwal, Christiana Dimitropoulou, Qing Lu, SM Black and Shruti Sharma (CorrespondingAuthor). ‘Glutathione Supplementation Attenuates Lipopolysaccharide-inducedMitochondrial Dysfunction and Apoptosis in a Mouse Model of Acute Lung Injury Front. Physiol.; 3:161. May 28, Epub 2012.

13. Shruti Sharma*, Xutong Sun*,Ruslan Rafikov, Sanjiv Kumar, Imran Rehmani, Suphin Kallarackal, Yali Hou,Peter Oishi, Sanjeev Datar, Gary Raff, JR Fineman, SM Black. ‘PPAR-γ regulatescarnitine homeostasis and mitochondrial function in a lamb model of increased pulmonaryblood flow’ PLOS One; 7(9): Epub 2012.

14. Xutong Sun*, Shruti Sharma*, Sohrab Fratz*, Sanjiv Kumar, Ruslan Rafikov,Saurabh Aggarwal, Olga Rafikova, Qing Lu, Tantiana Burns, Sridevi Dasarathy,Christian Schreiber, Jeffrey Fineman and Stephen Black. ‘Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow’. Antioxid and redoxsignaling Dec 17. (Epub 2012).

15. Peter Oishi, Shruti Sharma, Sanjeev Datar, Sanjiv Kumar, Gary Raff,Anthony Azakie, Jong-Hau Hsu, Eniko Sajti, Sohrab Fratz, Stephen Black, Jeffrey Fineman. ‘Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow’ Pediatric Research Epub, Nov 5, 2012.

16. Anea Ciprian, Bo Cheng, Shruti Sharma,Sanjiv Kumar, Lin Yao, William Caldwell, Irfan Ali, Ana Merloiu, David Stepp, StephenBlack, David Fulton and Daniel Rudic. ‘Increased Superoxide and eNOS Uncoupling in Blood Vessels of Bmal1-KO mice’. Circulation Research, Epub, August 20, 2012.

17. TomRau, Qing Lu, Shruti Sharma, Xutong Sun, Leary G, Beckman ML, Yali Hou, Wainwright MS, Kavanaugh M, Poulsen DJ, Black SM. ‘Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction’. PLOS One; 7(9):e40881. Epub 2012.

18. Olga Rafikova, Ruslan Rafikov, SanjivKumar, Shruti Sharma, Saurabh Aggarwal, Frank Schneider, Stephen Black, and Stevan Tofovic. ‘Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension’. Free Radic BiolMed. Nov (Epub 2012).

19. Sanjiv Kumar*, Peter Oishi*, RuslanRafikov, Saurabh Aggarwal, Yali  Hou,Sanjiv Datar, Shruti Sharma, Anthony Azakie, Jeffrey Fineman, Stephen Black. ‘Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow’. J Cell Biochem.  Sep 7 (Epub 2012).

20. GL Pierce, KL Jablonski, AE Walker, SMSeibert, AE Devan, SM Black, Shruti Sharma, DR Seals. ‘Tetrahydrobiopterin Supplementation Enhances Carotid Artery Compliance in Healthy Older Men: A Pilot Study’. Am J Hypertens. 2012 Jun 7 [Epub].

21. Sohrab Fratz, Jeffrey Fineman, Agnes Görlach, Shruti Sharma, Peter Oishi, Christian Schreiber, Thomas Kietzmann, Ian Adatia, John Hess and Stephen Black. Early Determinants of Pulmonary Vascular Remodeling in Animal Models of Complex Congenital Heart Disease. Circulation.2011 Mar 1;123(8):916-23.

22. Xutong Sun, Sohrab Fratz, Shruti Sharma, Yali Hou, JingTian, Sanjiv Kumar, Ruslan Rafikov, Anita Smith, Imran Rehmani, John Catravas,Cam Patterson, Jeffrey Fineman, Stephen Black. C-terminus of heat shock protein70-interacting protein dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow. AmJ Respir Cell Mol Biol. 2011 Jul; 45(1):163-71.

23. Shruti Sharma,*Edyta Szurek,* Jacek Rzucidlo, Sean Liour, Ali Eroglu. ‘Effective Cryobankingof Embryoid Bodies to Facilitate Basic Research and Cell-Based Therapies’ Rejuvenation Res.2011; Dec 14:641-9.

24. Shruti Sharma,Sanjiv Kumar, Dean Wiseman, Manal Elgaish, Jeffrey Fineman, Stephen M. Black.Perinatal changes in superoxide generation in the ovine lung: alterations associated with increased pulmonary blood flow. Vascular Pharmacology. 2010; 53:38-52.

25. Shruti Sharma,Anita Smith, Sanjiv Kumar, Imran Rehmani, Jeffrey Fineman, Stephen M. Black.Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lunginjury: Role of asymmetric dimethylarginine. Vascular Pharmacology 2010; 52:182-90.

26. NFRossi, M Maliszewska-Scislo, H Chen, SM Black, Shruti Sharma, R Ravikov, RA Augustyniak. Neuronal NitricOxide Synthase within Paraventricular Nucleus: Blood Pressure and Baroreflex inTwo Kidney-One Clip Hypertensive Rats. Exp Physiol. 2010;95:845-57.

27. DeanWiseman, Shruti Sharma andStephen M. Black. Elevated zinc induces endothelial apoptosis via disruption of glutathione metabolism: Role of the ADP translocator. Biometals. 2010;23:19-30.

28. Shruti Sharma,Sanjiv Kumar, Neetu Sud, Dean Wiseman, Jing Tian, Imran Rehmani, Sanjeev Datar,Peter Oishi, Sohrab Fratz, Richard C. Venema, Jeffrey R. Fineman, and StephenM. Black. ‘Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow’. Vascular Pharmacology. 2009; 51:359-64.

29. Shruti Sharma and Stephen M. Black. ‘Carnitine homeostasis, mitochondrial function andcardiovascular disease’. DrugDiscovery Today: Disease Mechanisms 2009; 6:e31-e39.

30. SanjivKumar*, Xutong Sun*, Shruti Sharma, Saurabh Aggarwal, Kandasamy Ravi, Jeffery Fineman and Stephen M. Black. GTPcyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP. Am J Physiol Lung Cell Mol Physiol. 2009; 297:L309-17.

31. Shruti Sharma, Neetu Sud, Dean A. Wiseman, A. Lee Carter, Sanjiv Kumar, Yali Hou, Thomas Rau, Jason Wilham, Cynthia Harmon, Peter Oishi, Jeffrey R. Fineman, and Stephen M.Black. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension. Am J Physiol LungCell MolPhysiol. 2008; 294:L46-56.

32. NeetuSud*, Sandra M. Wells*, Shruti Sharma,Dean A. Wiseman, Jason Wilham, and Stephen M. Black. Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction. Am J Physiol Cell Physiol. 2008; 294(6):C1407-18. 

33. Peter Oishi, Dean Wiseman, Shruti Sharma,Sanjiv Kumar, Yali Hou, Sanjeev Datar, Anthony Azakie, Michael Johengen,Cynthia Harmon, Sohrab Fratz, Jeffrey Fineman, and Stephen Black. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol: 2008;295:L756-66.

34. Shruti Sharma*,Albert Grobe*, Dean Wiseman, Sanjiv Kumar, Manal Englaish, Ida Najwer, Eileen Benavidez, Peter Oishi, Anthony Azakie, Jeffrey Fineman, and Stephen Black.Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow. Am J Physiol LungCell Mol Physiol. 2007; 293:L960-71.

35. Neetu Sud, Shruti Sharma, Dean Wiseman, Cynthia Harmon, Sanjiv Kumar, Richard Venema, Jeffrey Fineman, and Stephen Black. Nitric oxide and superoxide generation from endothelial NOS:modulation by HSP90. Am JPhysiol Lung Cell Mol Physiol 2007 Dec; 293(6):L1444-53.

36. Peter Oishi, Shruti Sharma, Albert Grobe, Anthony Azakie, Cynthia Harmon, Michael Johengen, Jong-Hau Hsu, Sohrab Fratz, Stephen Black, Jeffrey Fineman. Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs. Pediatric Pulmonology.2007;42:1057-71.

37. Mark Wainwright, Dava Grundhoefer, ShrutiSharma and Stephen Black. A nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat. NeuroscienceLetters, 2007; 415:124-9.

 

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